Effect
of Co-administration of Cassava (Manihot Esculenta Crantz)
Rich Diet and Alcohol in Rats
Boby R. G. and M. Indira*
Department of Biochemistry,
University of Kerala,
Kariavattom, Thiruvananthapuram – 695 581
( Received on May 14, 2003 )
click
here for full article in pdf
Abstract
The effects of co-administration of a cassava rich
diet and alcohol in rats were investigated. The animals were divided
into four groups (1) Control, (2) Alcohol, (3) Cassava and (4)
Alcohol + Cassava. Consumption of alcohol along with cassava reduced
the alcohol induced toxicity which was evidenced by the lower
activities of GOT, GPT, GGT, acid phosphatase and alkaline phosphatase
in the liver and serum of co-administered group. The pyruvate
content in the blood increased while the lactate content, lactate/pyruvate
ratio and the activity of LDH decreased in the blood due to co-administration.
The blood cyanide content, serum thiocyanate content and the activities
of rhodanase and b-glucuronidase increased on co-administration.
The histopathological studies also revealed that co-administration
reduced the alcohol induced toxicity.
