Oxidative Stress and Antioxidants Status in Peptic Ulcer and Gastric Carcinoma

R. Tandon 1, H. D. Khanna2, M. Dorababu3 and R K. Goel 3*

Divisions of Medicine1, Biophysics2 and Pharmacology3,
Institute of Medical Sciences,
Banaras Hindu University,
Varanasi – 221 005

( Received on December 28, 2002 )

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Abstract

Oxidative stress is believed to initiate and aggravate many diseases including peptic ulcers and gastric carcinoma. We observed an increase in rat gastric mucosal lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in cold restraint stress-induced gastric ulceration while, in clinical peptic ulceration and gastric carcinoma patients, an increase in serum LPO and a tendency to decrease in SOD and CAT levels were observed. The result thus, indicated a positive correlation between free radical-induced oxidative stress both in gastric and duodenal ulcers and gastric carcinoma.