Effect
of Extracts Of
Murraya koenigii Leaves On
The Levels of Blood Glucose and Plasma Insulin in Alloxan-Induced
Diabetic Rats
Vinuthan
M. K., Girish Kumar V., Ravindra J. P., *Jayaprakash and **Narayana
K.
Departments of Veterinary Physiology, *Biochemistry and
**
Pharmacology and Toxicology,
Veterinary College, UAS, Hebbal,
Bangalore – 560 024
( Received on Sept 2, 2003)
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Abstract : The effect of daily oral administration of aqueous
extract (600 mg/kg b.wt.) and methanol extract (200 mg/kg b.wt.)
of Murraya koenigii Spreng leaves for a period of eight
weeks was studied on blood glucose and plasma insulin level in
alloxan-induced diabetic rats. Blood glucose levels of diabetic
rats treated with aqueous and methanol extracts of Murraya
koenigii Spreng showed significant reduction (P<0.05) as
compared to diabetic control groups. Plasma insulin showed
significantly high on 43rd and 58th days of treatment in aqueous
and methanol extracts of Murraya koenigii treated groups.
This suggests that the hypoglycemic effect may be mediated through
stimulating insulin synthesis and/or secretion from the beta cells
of pancreatic islets of Langerhans.
Key words :
murraya koenigii
alloxan
diabetes
glucose
insulin
hypoglycemia aqueous extract
methanol extract
